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KMID : 0378019710140010117
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New Medical Journal
1971 Volume.14 No. 1 p.117 ~ p.120
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Clinical Observation of Bactrim^(®) in Typhoid Fever
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金大河/Kim, D.H.
李重根/李昌弘/李宰燮/魯炳鎬/Lee, C.K./Lee, C.H./Lee, J.S./Lee, B.H.
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Abstract
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The Present study was carried out in order to evaluate the therapeutic effect of Bactrim in 23 selected patients with typhoid fever who were admitted to the Department of Internal Medicine, Seoul National University Hospital during the 5 months period from March to July, 1970. They consisted of 14 males and 9 females. The age was ranged from 16 to 57 years, with mean age of 34.2.
The patients included were bacteriologically (positive blood or stool culture) and serologically (Widal reaction above 1:160 in titer) confirmed cases and they did not take any antibiotic prior to admission. Bactrim was given orally 4 tablets daily in 2 divided doses for 14 days. Baseline studies including complete blood counts, urinalysis, stool examination, tests for bleeding tendency, liver function tests and bacteriologic sensitivity tests were done before administration of the drug and they were repeated at intervals 3 to 4 times thereafter by the time of discharge. E. K. G was also checked before and after treatment.
Bactrim was effective in 21 (91.3%) out of 23 patients and the duration of fever after treatment was ranging from 3 to 7 days in responded cases. Treatment failure was considered to occur if fever did not subside within 10 days after initiation of therapy. There were 2 treatment failures. Two cases of relapse and one case of side reaction of the drug were noted in this study.
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